ABSTRACT
OBJECTIVE@#To study the risk factors and interaction of nasal septal perforation (NSP) in rats.@*METHOD@#Animals (n=120) that underwent unilateral nasal obstruction using Merocel nasal packing or gelfoam with/without standard staphylococcus aureus inoculation were observed for the formation of NSP at 2, 3, 5, and 7 days after operation by endoscope system. Following sacrifice at 7 days, the obtained nasal secretions were prepared for bacterial culture. Experimental interventions were compared with normal controls (n=10).@*RESULT@#Perforation of nasal septum was observed in 80% of the animals accepted nasal obstruction using Merocel nasal packing with standard staphylococcus aureus inoculation in 3 days (P 0.05). There was a weak region in anteroinferior nasal septum in rats, which the almost NSPs located in. The position of NSP does not overlap Merocel.@*CONCLUSION@#The interaction of risk factors contributes to NSP. The occurrence of NSP mainly depends on the construction of nasal septum, while dysaemia is also necessary. Obstruction of nasal drainage and infection promote the development of NSP.
Subject(s)
Animals , Male , Rats , Causality , Disease Models, Animal , Nasal Obstruction , Microbiology , Pathology , Nasal Septal Perforation , Nasal Septum , Rats, Sprague-Dawley , Risk Factors , Staphylococcal Infections , PathologyABSTRACT
Objective To investigate the outcome of powered laryngeal shaver for papilloma of the larynx in children by laryngeal endoscopy. Methods Thirty-nine children with papilloma of the larynx were treated by powered laryngeal shaver under a laryngeal endoscope. Twenty-seven of the patients who had an extensive tumor received radiofrequency to avoid hemorrhage and adhesion of the surgical surface. Results The mean operation time was (11.2?2.6) min, and the blood lose was less than 30 ml. Three months after the operation, 28 of the patients were fond of their voice quality. Among the 39 patients, 37 were followed up for 2-5 years, during which 3-year recurrence rate was 51% (19/37). In the children with primary patients, the rate of recurrence was 30% (3/10), and in those with recurrent tumor, the rate was 59% (16/27). Conclusions By using powered laryngeal shaver under a laryngeal endoscope, papilloma of the larynx can be accurately resected with low blood loss, short operation time and short hospital stay and confirmed effectivenss.
ABSTRACT
AIM To study the chemical constituents of the seeds from Artabotrys hexapetalus (L.f.) Bhandari (Annonaceae). METHODS Various chromatographic techniques were used to separate and purify the constituents. Their structures were elucidated on the physico-chemical properties and spectral data. RESULTS Eight compounds were isolated from the seeds of A.hexapetalus. They were identified as four neolignans: isoamericanin A (1), isoamericanol A (2), americanin B (3) and artabotrycinol (4), a semiterpenoid: (R)-artabotriol (5) and others: palmitic acid (6), β-sitosterol (7) and daucosterol (8). CONCLUSION Artabotrycinol (4) and (R)-artabotriol (5) are new compounds. Three other neolignans were isolated from this plant for the first time.